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Klbtm1(cre)Mglm
Targeted Allele Detail
Summary
Symbol: Klbtm1(cre)Mglm
Name: klotho beta; targeted mutation 1, Matthew Gillum
MGI ID: MGI:6727118
Synonyms: Klb-CRE
Gene: Klb  Location: Chr5:65505657-65541350 bp, + strand  Genetic Position: Chr5, 33.64 cM
Alliance: Klbtm1(cre)Mglm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:296603
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Klbtm1(cre)Mglm expression driven by 1 gene
 
Mutation details: The allele was generated by inserting, in frame with the b-klotho (gene symbol: Klb) ATG in exon 1, a construct containing the CRE recombinase and the tdTomato reporter coding sequence separated by an IRES sequence via homologous recombination. (J:296603)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Klb (mouse)
Summary of all recombinase alleles driven by Klb.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klb Mutation:  58 strains or lines available
References
Original:  J:296603 Jensen-Cody SO, et al., FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. Cell Metab. 2020 Aug 4;32(2):273-286.e6
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/19/2024
MGI 6.24 		The Jackson Laboratory