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Cdkn2atm1.1(cre)Dvb
Targeted Allele Detail
Summary
Symbol: Cdkn2atm1.1(cre)Dvb
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1.1, Dmitry V Bulavin
MGI ID: MGI:6727119
Synonyms: p16-Cre
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance: Cdkn2atm1.1(cre)Dvb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:296551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Cdkn2atm1.1(cre)Dvb expression driven by 1 gene
 
Mutation details: A F2A-Cre-T2A-TK-E2A-tdTomato cassette was introduced at the end of the last exon of the Cdkn2a (p16Ink4) gene by homologous recombination in the ES cells. The Frt-loxed Neo cassette was removed by crossing with FLP deleter. (J:296551)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdkn2a (mouse)
Summary of all recombinase alleles driven by Cdkn2a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  67 strains or lines available
References
Original:  J:296551 Grosse L, et al., Defined p16(High) Senescent Cell Types Are Indispensable for Mouse Healthspan. Cell Metab. 2020 Jul 7;32(1):87-99.e6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory