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Sp8tm1.1(flpo/ERT2)Tmj
Targeted Allele Detail
Summary
Symbol: Sp8tm1.1(flpo/ERT2)Tmj
Name: trans-acting transcription factor 8; targeted mutation 1.1, Thomas M Jessell
MGI ID: MGI:6728071
Synonyms: Sp8::FlpoERT2
Gene: Sp8  Location: Chr12:118810064-118816311 bp, + strand  Genetic Position: Chr12, 63.48 cM
Alliance: Sp8tm1.1(flpo/ERT2)Tmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234419
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Sp8tm1.1(flpo/ERT2)Tmj expression driven by 1 gene
 
Mutation details: A codon-optimized version of FLP recombinase was fused to ERT2 and inserted into the ATG of the endogenous Sp8 locus by ES cell recombination. The neomycin selectable cassette was removed by crossing with cre-deleter. This is a null allele as well as recombinase knock-in. (J:234419)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sp8 (mouse)
Summary of all recombinase alleles driven by Sp8.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp8 Mutation:  29 strains or lines available
References
Original:  J:234419 Bikoff JB, et al., Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits. Cell. 2016 Mar 24;165(1):207-19
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory