Pdgfratm2.1(flpo)Leol
Targeted Allele Detail
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| Symbol: |
Pdgfratm2.1(flpo)Leol |
| Name: |
platelet derived growth factor receptor, alpha polypeptide; targeted mutation 2.1, Lorin E Olson |
| MGI ID: |
MGI:6728539 |
| Synonyms: |
PdgfraFlp |
| Gene: |
Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
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| Alliance: |
Pdgfratm2.1(flpo)Leol page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:306160
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Conditional ready, No functional change, Recombinase) |
| Mutations: |
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Insertion, Intragenic deletion
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Pdgfratm2.1(flpo)Leol expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Pdgfra (MGI:97530) |
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Mutation details: The targeting cassette consisting of a SA.lox.PDGFRa.lox-Flpo-attB-Neo-attP cassette replaced the exons 2-4 of the endogenous Pdgfra gene. The PDGFRa is a mouse Pdgfra gene cDNA. PhiC31 integrase removed the attB-Neo-attP cassette. Cre-mediated recombination is required to achieve expression of the flpo recombinase.
(J:306160)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Pdgfra
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pdgfra Mutation: |
87 strains or lines available
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| Original: |
J:306160 Sun C, et al., Mosaic Mutant Analysis Identifies PDGFRalpha/PDGFRbeta as Negative Regulators of Adipogenesis. Cell Stem Cell. 2020 May 7;26(5):707-721.e5 |
| All: |
2 reference(s) |
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Analysis Tools
