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Pdgfratm1.1(flpo)Leol
Targeted Allele Detail
Summary
Symbol: Pdgfratm1.1(flpo)Leol
Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1.1, Lorin E Olson
MGI ID: MGI:6731084
Synonyms: aRdeltaK.Flp, PdgfradeltaK.Flp
Gene: Pdgfra  Location: Chr5:75312953-75358876 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Pdgfratm1.1(flpo)Leol page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:306160
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Constitutively active, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Pdgfratm1.1(flpo)Leol expression driven by 1 gene
 
Mutation details: The targeting cassette consisting of a SA.lox.Neo/Stop.lox-PDGFRaK.T2A.Flp cassette replaced the exons 2-4 of the endogenous Pdgfra gene. The PDGFRaK is a mouse Pdgfra gene cDNA with a point mutation (D842V) renders it constitutively active. Cre-mediated recombination removed lox.Neo/Stop.lox cassette from Pdgfratm1(flpo)Leol enabling the expression of the constitutively active Pdgfra gene with a point mutation (D842V) and the flpo recombinase. (J:306160)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdgfra (mouse)
Summary of all recombinase alleles driven by Pdgfra.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfra Mutation:  88 strains or lines available
References
Original:  J:306160 Sun C, et al., Mosaic Mutant Analysis Identifies PDGFRalpha/PDGFRbeta as Negative Regulators of Adipogenesis. Cell Stem Cell. 2020 May 7;26(5):707-721.e5
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory