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Il17atm2.1(EGFP/cre/ERT2)Flv
Targeted Allele Detail
Summary
Symbol: Il17atm2.1(EGFP/cre/ERT2)Flv
Name: interleukin 17A; targeted mutation 2.1, Richard A Flavell
MGI ID: MGI:6739820
Synonyms: IL-17A IRES-eGFP-CRE-ERT2
Gene: Il17a  Location: Chr1:20801129-20804720 bp, + strand  Genetic Position: Chr1, 6.45 cM, cytoband A
Alliance: Il17atm2.1(EGFP/cre/ERT2)Flv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224098
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Il17atm2.1(EGFP/cre/ERT2)Flv expression driven by 1 gene
 
Mutation details: A cassette encoding for a fusion protein consisting of the Internal Ribosome Entry Site (IRES), eGFP, Cre and human-modified Oestrogen Receptor (ERT2) (IGCE) was linked to a Frt-flanked neomycin (NEO) encoding cassette and inserted downstream of the translation stop codon in the mouse Il17a gene by targetted homologous recombination in ES cells. Germline transmitted mice were bred with germline Flippase expressing transgenic mice to remove the neomycin gene. (J:224098)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Il17a (mouse)
Summary of all recombinase alleles driven by Il17a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17a Mutation:  25 strains or lines available
References
Original:  J:224098 Gagliani N, et al., Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 2015 Jul 9;523(7559):221-5
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory