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Ncr1tm1(icre/ERT2)Tfen
Targeted Allele Detail
Summary
Symbol: Ncr1tm1(icre/ERT2)Tfen
Name: natural cytotoxicity triggering receptor 1; targeted mutation 1, Todd A Fehniger
MGI ID: MGI:6739825
Synonyms: Ncr1-iCreERT2
Gene: Ncr1  Location: Chr7:4340723-4348163 bp, + strand  Genetic Position: Chr7, 2.5 cM
Alliance: Ncr1tm1(icre/ERT2)Tfen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292090
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ncr1tm1(icre/ERT2)Tfen expression driven by 1 gene
 
Mutation details: Via homologous recombination in ES cells, the targeting vector inserted tamoxifen-responsive iCreERT2 cassette into the Ncr1 locus linked to the C-terminal translation via a P2A ribosomal skip site. (J:292090)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ncr1 (mouse)
Summary of all recombinase alleles driven by Ncr1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncr1 Mutation:  40 strains or lines available
References
Original:  J:292090 Wagner JA, et al., Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity. Cell Rep. 2020 Jun 2;31(9):107720
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory