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Cpne7tm1.1(cre)Sleep
Targeted Allele Detail
Summary
Symbol: Cpne7tm1.1(cre)Sleep
Name: copine VII; targeted mutation 1.1, Yu Hayashi
MGI ID: MGI:6739829
Synonyms: Cpne7Cre, Cpne7-KO
Gene: Cpne7  Location: Chr8:123844113-123861921 bp, + strand  Genetic Position: Chr8, 72.06 cM
Alliance: Cpne7tm1.1(cre)Sleep page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:291955
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Cpne7tm1.1(cre)Sleep expression driven by 1 gene
 
Mutation details: Via homologous recombination in ES cells, the targeting vector inserted a nuclear localization sequence(NLS)-Cre-FRT-PGK-gb2-neo-FRT cassette (Cre cassette) downstream of the Cpne7 promoter. The PGK-Neo cassette was removed by crossing mice with CAG-FLPe mice. The western blot of whole brain samples did not show the detectable level of Cpne7 protein in homozygous mice. It is a null allele. (J:291955)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cpne7 (mouse)
Summary of all recombinase alleles driven by Cpne7.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpne7 Mutation:  26 strains or lines available
References
Original:  J:291955 Liu CY, et al., Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice. Neurosci Res. 2020 Apr 11;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory