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Lrp4tm1.1(GFP/cre/ERT2)Gan
Targeted Allele Detail
Summary
Symbol: Lrp4tm1.1(GFP/cre/ERT2)Gan
Name: low density lipoprotein receptor-related protein 4; targeted mutation 1.1, Lin Gan
MGI ID: MGI:6739898
Synonyms: Lrp4-CreERT2
Gene: Lrp4  Location: Chr2:91287856-91344124 bp, + strand  Genetic Position: Chr2, 50.63 cM
Alliance: Lrp4tm1.1(GFP/cre/ERT2)Gan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:291055
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lrp4tm1.1(GFP/cre/ERT2)Gan expression driven by 1 gene
 
Mutation details: A targeting vector containing a 3' FRT flanked neo cassette and P2A-GFP-CreERT2 cassette was inserted to exon 38 of the Lrp4 gene via homologous recombination in C57BL/6J-derived embryonic stem cells. Heterozygous animals were crossed subsequently to FLP recombinase expressing mice to remove the FRT site flanked PGK-neo cassette. (J:291055)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lrp4 (mouse)
Summary of all recombinase alleles driven by Lrp4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp4 Mutation:  98 strains or lines available
References
Original:  J:291055 Zhang H, et al., A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Abeta Clearance. J Neurosci. 2020 Jul 8;40(28):5347-5361
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
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