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Grprem1(icre/ERT2)Ygs
Endonuclease-mediated Allele Detail
Summary
Symbol: Grprem1(icre/ERT2)Ygs
Name: gastrin releasing peptide receptor; endonuclease-mediated mutation 1, Yan-Gang Sun
MGI ID: MGI:6740210
Synonyms: GRPR-iCreERT2
Gene: Grpr  Location: ChrX:162296900-162332673 bp, - strand  Genetic Position: ChrX, 75.63 cM
Alliance: Grprem1(icre/ERT2)Ygs page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Grprem1(icre/ERT2)Ygs expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technology, a cassette comprising of the 2A-linked optimized Cre recombinase fused with the ligand-binding domain of the estrogen receptor (2A-iCreERT2) was inserted in the Exon3 and 3UTR of Grpr gene. (J:244217)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Grpr (mouse)
Summary of all recombinase alleles driven by Grpr.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grpr Mutation:  14 strains or lines available
References
Original:  J:244217 Mu D, et al., A central neural circuit for itch sensation. Science. 2017 Aug 18;357(6352):695-699
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory