About   Help   FAQ
Sox6tm2.1(cre/ERT2)Awar
Targeted Allele Detail
Summary
Symbol: Sox6tm2.1(cre/ERT2)Awar
Name: SRY (sex determining region Y)-box 6; targeted mutation 2.1, Rajeshwar Awatramani
MGI ID: MGI:6740239
Synonyms: Sox6-CreERT2
Gene: Sox6  Location: Chr7:115070107-115638031 bp, - strand  Genetic Position: Chr7, 61.29 cM
Alliance: Sox6tm2.1(cre/ERT2)Awar page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:290856
Parent Cell Line:  PRX-B6N (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Sox6tm2.1(cre/ERT2)Awar expression driven by 1 gene
 
Mutation details: The FRT-STOP-Puro-FRT cassette was inserted into the intronic region between exons 2 and 3 and a NLS-Cre/ERT2-polyA was inserted into the Sox6 gene in-frame to the endogenous ATG. Flp-mediated recombination removed the STOP and selection cassette. (J:290856, J:321252)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sox6 (mouse)
Summary of all recombinase alleles driven by Sox6.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox6 Mutation:  60 strains or lines available
References
Original:  J:290856 Poulin JF, et al., PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages. Dev Cell. 2020 Jun 22;53(6):740-753.e3
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory