About   Help   FAQ
Hic1tm2.1(cre/ERT2)Tmun
Targeted Allele Detail
Summary
Symbol: Hic1tm2.1(cre/ERT2)Tmun
Name: hypermethylated in cancer 1; targeted mutation 2.1, T Michael Underhill
MGI ID: MGI:6740447
Synonyms: Hic1CreERT2
Gene: Hic1  Location: Chr11:75055391-75060345 bp, - strand  Genetic Position: Chr11, 45.76 cM
Alliance: Hic1tm2.1(cre/ERT2)Tmun page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292396
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Hic1tm2.1(cre/ERT2)Tmun expression driven by 1 gene
 
Mutation details: A targeting vector introduced an IRES-CreERT2 cassette along with an FRT flanked PGKneo cassette into the 3' untranslated region of the Hic1 gene. Male chimeras were subsequently bred to Flippase-expressing mice to delete the PGK-neo cassette. (J:292396)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hic1 (mouse)
Summary of all recombinase alleles driven by Hic1.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hic1 Mutation:  36 strains or lines available
References
Original:  J:292396 Scott RW, et al., Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration. Cell Stem Cell. 2019 Dec 5;25(6):797-813.e9
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory