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Aqp5tm1.1(cre/ERT2)Ptch
Targeted Allele Detail
Summary
Symbol: Aqp5tm1.1(cre/ERT2)Ptch
Name: aquaporin 5; targeted mutation 1.1, Pao-Tien Chuang
MGI ID: MGI:6741118
Synonyms: Aqp5CreER
Gene: Aqp5  Location: Chr15:99488909-99492710 bp, + strand  Genetic Position: Chr15, 56.13 cM
Alliance: Aqp5tm1.1(cre/ERT2)Ptch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:290280
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Aqp5tm1.1(cre/ERT2)Ptch expression driven by 1 gene
 
Mutation details: A cre/ER fusion construct followed by an FRT flanked PGK neo selection cassette was inserted to replace the ATG translational start codon. The selection cassette was subsequently removed by crossing properly targeted mice to mice expressing flp recombinase. (J:290280)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Aqp5 (mouse)
Summary of all recombinase alleles driven by Aqp5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp5 Mutation:  19 strains or lines available
References
Original:  J:290280 Zhang K, et al., A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. Elife. 2020 May 12;9:e53688
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory