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Klrb1ctm1.1(icre)Tlaw
Targeted Allele Detail
Summary
Symbol: Klrb1ctm1.1(icre)Tlaw
Name: killer cell lectin-like receptor subfamily B member 1C; targeted mutation 1.1, Toby Lawrence
MGI ID: MGI:6754098
Synonyms: Cd163-iCre
Gene: Klrb1c  Location: Chr6:128755448-128765514 bp, - strand  Genetic Position: Chr6, 63.09 cM
Alliance: Klrb1ctm1.1(icre)Tlaw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:289994
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Klrb1ctm1.1(icre)Tlaw expression driven by 1 gene
 
Mutation details: A FlpO-NeoR cassette encoding IRES-iCre was inserted in the 3' untranslated region of the Klrb1c gene using homologous recombination and used to generate chimeric mice that were subsequently crossed to Flp deleter mice to facilitate removal of the NeoR cassette. (J:289994)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Klrb1c (mouse)
Summary of all recombinase alleles driven by Klrb1c.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klrb1c Mutation:  22 strains or lines available
References
Original:  J:289994 Etzerodt A, et al., Specific targeting of CD163(+) TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression. J Exp Med. 2019 Oct 7;216(10):2394-2411
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory