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Prlhem1(cre)Mgmj
Endonuclease-mediated Allele Detail
Summary
Symbol: Prlhem1(cre)Mgmj
Name: prolactin releasing hormone; endonuclease-mediated mutation 1, Martin G Myers, Jr
MGI ID: MGI:6757218
Synonyms: Prlhcre
Gene: Prlh  Location: Chr1:90880830-90881749 bp, + strand  Genetic Position: Chr1, 45.81 cM
Alliance: Prlhem1(cre)Mgmj page
Mutation
origin
Strain of Origin:  (C57BL/6J x SJL)F2
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Prlhem1(cre)Mgmj expression driven by 1 gene
    CRISPR/cas9 genome editing is used to insert an IRES and Cre recombinase at the stop codon. (J:309169)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Prlh (mouse)
Summary of all recombinase alleles driven by Prlh.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prlh Mutation:  7 strains or lines available
References
Original:  J:309169 Cheng W, et al., NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 Aug 30;12(1):5175
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory