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Gsx2em1(flpo)Bche
Endonuclease-mediated Allele Detail
Summary
Symbol: Gsx2em1(flpo)Bche
Name: GS homeobox 2; endonuclease-mediated mutation 1, Bin Chen
MGI ID: MGI:6758119
Synonyms: Gsx2Flpo
Gene: Gsx2  Location: Chr5:75236262-75238554 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Gsx2em1(flpo)Bche page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Gsx2em1(flpo)Bche expression driven by 1 gene
 
Mutation details: Using a CRISPR/Cas9 based strategy, a P2A-Flpo-T2A-Flpo DNA cassette was inserted between the protein-coding sequences of exon 2 and 3' UTR of the Gsx2 gene. (J:288251)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gsx2 (mouse)
Summary of all recombinase alleles driven by Gsx2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gsx2 Mutation:  18 strains or lines available
References
Original:  J:288251 Zhang Y, et al., Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog. Cell Rep. 2020 Mar 31;30(13):4490-4504.e4
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory