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Trpc5tm1.1(cre)Dbru
Targeted Allele Detail
Summary
Symbol: Trpc5tm1.1(cre)Dbru
Name: transient receptor potential cation channel, subfamily C, member 5; targeted mutation 1.1, Dieter Bruns
MGI ID: MGI:6758141
Synonyms: TRPC5-IC, TRPC5-IRES-Cre
Gene: Trpc5  Location: ChrX:143164667-143471176 bp, - strand  Genetic Position: ChrX, 65.49 cM, cytoband F2
Alliance: Trpc5tm1.1(cre)Dbru page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:287788
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Trpc5tm1.1(cre)Dbru expression driven by 1 gene
 
Mutation details: The targeting construct inserted an IRES-Cre-pgk promoterdriven Flp recombination target (FRT)neomycin (neo)FRT cassette into final exon 11 of the Trpc5 gene by homologous recombination in ES cells. The FRT flanked neo selection cassette was removed by FLP-deleter mice. (J:287788)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Trpc5 (mouse)
Summary of all recombinase alleles driven by Trpc5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpc5 Mutation:  21 strains or lines available
References
Original:  J:287788 Schwarz Y, et al., TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses. PLoS Biol. 2019 Sep;17(9):e3000445
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory