Prkntm1Tchi
Targeted Allele Detail
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| Symbol: |
Prkntm1Tchi |
| Name: |
parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Tomoki Chiba |
| MGI ID: |
MGI:6758222 |
| Synonyms: |
Parkin- |
| Gene: |
Prkn Location: Chr17:11059271-12282248 bp, + strand Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
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| Alliance: |
Prkntm1Tchi page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Most of exon 2 was replaced in-frame by the coding sequence of tau (Mapt) and green fluorescent protein (GFP), followed by translation and transcription termination sequences and the MC1-neomycin cassette. Western blot analysis confirmed the absence of protein in the brain. RT-PCR confirmed the presence of GFP transcripts, however the parkin-tau-GFP fusion protein is not clearly detectable by Western blot or immunohistochemical analysis.
(J:309429)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Prkn Mutation: |
54 strains or lines available
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| Original: |
J:309429 Sato S, et al., Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography. J Neurosci Res. 2006 Nov 1;84(6):1350-7 |
| All: |
3 reference(s) |
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Analysis Tools
