Fbxo6<tm1Yuyos> Targeted Allele Detail MGI Mouse (MGI:6758506)

Fbxo6^tm1Yuyos
Targeted Allele Detail

Summary

Symbol:	Fbxo6^tm1Yuyos
Name:	F-box protein 6; targeted mutation 1, Yukiko Yoshida
MGI ID:	MGI:6758506
Gene:	Fbxo6 Location: Chr4:148230173-148236592 bp, - strand Genetic Position: Chr4, 78.67 cM
Alliance:	Fbxo6^tm1Yuyos page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:307684
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The targeting construct replaced part of exon 1 and exons 2 to 4 with a neomycin resistance cassette with a 5' loxP site. (J:307684)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fbxo6 Mutation:	34 strains or lines available

Notes

This allele was generated in the same targeting event as Fbxo2^tm1Tasuz.

References

Original:	J:307684 Yoshida Y, et al., Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2102902118
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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