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Tg(Mnx1-cre/ERT2)8Rbro
Transgene Detail
Summary
Symbol: Tg(Mnx1-cre/ERT2)8Rbro
Name: transgene insertion 8, Robert M Brownstone
MGI ID: MGI:6758656
Synonyms: Hb9::CreERT2
Transgene: Tg(Mnx1-cre/ERT2)8Rbro  Location: unknown  
Alliance: Tg(Mnx1-cre/ERT2)8Rbro page
Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Mnx1-cre/ERT2)8Rbro expression driven by 1 gene
 
Mutation details: The bacterial artificial chromosome (BAC) clone RP24-351I23 containing the mouse Mnx1 (Hb9) gene was modified using recombineering bacterial strain to introduce the cre/ERT2-BGH polyA and Frt-Zeo-Frt selection cassette into the exon 1 replacing the Mnx1 coding region. The Frt-Zeo-Frt cassette is retained in the transgene but lacks a eukaryotic promoter. Three founder lines (4, 8, and 10) were generated. Line 10 gave low-level inducible activity and was terminated. Line 4 and Line 8 displayed similar inducible recombination activity in the desired cell populations and were maintained. Lines 4 and 8 were indistinguishable, and line 8 was used for the majority of studies described. (J:309433)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mnx1 (mouse)
Summary of all recombinase alleles driven by Mnx1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:309433 Koronfel LM, et al., Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion. Sci Rep. 2021 Aug 6;11(1):16008
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory