Tg(Mnx1-cre/ERT2)4Rbro
Transgene Detail
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| Symbol: |
Tg(Mnx1-cre/ERT2)4Rbro |
| Name: |
transgene insertion 4, Robert M Brownstone |
| MGI ID: |
MGI:6758657 |
| Synonyms: |
Hb9::CreERT2 |
| Transgene: |
Tg(Mnx1-cre/ERT2)4Rbro Location: unknown
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| Alliance: |
Tg(Mnx1-cre/ERT2)4Rbro page
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| Strain of Origin: |
C57BL/6 x CBA
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Mnx1-cre/ERT2)4Rbro expression driven by
1 gene
Transgene expression driven by:
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Mutation details: The bacterial artificial chromosome (BAC) clone RP24-351I23 containing the mouse Mnx1 (Hb9) gene was modified using recombineering bacterial strain to introduce the cre/ERT2-BGH polyA and Frt-Zeo-Frt selection cassette into the exon 1 replacing the Mnx1 coding region. The Frt-Zeo-Frt cassette is retained in the transgene but lacks a eukaryotic promoter. Three founder lines (4, 8, and 10) were generated. Line 10 gave low-level inducible activity and was terminated. Line 4 and Line 8 displayed similar inducible recombination activity in the desired cell populations and were maintained. Lines 4 and 8 were indistinguishable, and line 8 was used for the majority of studies described.
(J:309433)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Mnx1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:309433 Koronfel LM, et al., Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion. Sci Rep. 2021 Aug 6;11(1):16008 |
| All: |
1 reference(s) |
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Analysis Tools
