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Tbx21tm2.1(cre)Ayr
Targeted Allele Detail
Summary
Symbol: Tbx21tm2.1(cre)Ayr
Name: T-box 21; targeted mutation 2.1, Alexander Y Rudensky
MGI ID: MGI:6758783
Synonyms: Tbx21tdTomato-T2A-cre
Gene: Tbx21  Location: Chr11:96988897-97006157 bp, - strand  Genetic Position: Chr11, 60.95 cM, cytoband D
Alliance: Tbx21tm2.1(cre)Ayr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:248943
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Tbx21tm2.1(cre)Ayr expression driven by 1 gene
 
Mutation details: The IRES-tdTomato-T2A-Cre-frt-NEO-BGHpA-frt sequence was inserted into the Tbx21 3' UTR by homologous recombination in the ES cells. Mice were bred to FLPeR mice to excise the NEO cassette. (J:248943)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx21 (mouse)
Summary of all recombinase alleles driven by Tbx21.
 

Expression
In Mice Carrying this Mutation: 16 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx21 Mutation:  39 strains or lines available
References
Original:  J:248943 Levine AG, et al., Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017 Jun 15;546(7658):421-425
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory