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Diaph2tm2(CAG-cre/ERT2)Hna
Targeted Allele Detail
Summary
Symbol: Diaph2tm2(CAG-cre/ERT2)Hna
Name: diaphanous related formin 2; targeted mutation 1, Hiroyasu Nakano
MGI ID: MGI:6758921
Synonyms: Cre-ERT2 Tg
Gene: Diaph2  Location: ChrX:128650491-129366583 bp, + strand  Genetic Position: ChrX, 52.36 cM
Alliance: Diaph2tm2(CAG-cre/ERT2)Hna page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:286073
Parent Cell Line:  KTPU8 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Disruption caused by insertion of vector, Insertion
 
Diaph2tm2(CAG-cre/ERT2)Hna expression driven by 1 gene
 
Mutation details: RMCE of Diaph2Gt(Ayu21-B210)Imeg inserted a cre/ERT2 expression cassette under the control of the CAG promoter followed by puromycin selection cassette. (J:286073)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: CAG (chicken)
Summary of all recombinase alleles driven by CAG.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Diaph2 Mutation:  56 strains or lines available
References
Original:  J:286073 Shindo R, et al., Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. iScience. 2019 May 31;15:536-551
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory