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Olig1tm1.1(cre)Rth
Targeted Allele Detail
Summary
Symbol: Olig1tm1.1(cre)Rth
Name: oligodendrocyte transcription factor 1; targeted mutation 1.1, David H Rowitch
MGI ID: MGI:6759440
Synonyms: Olig1Cre
Gene: Olig1  Location: Chr16:91066660-91068821 bp, + strand  Genetic Position: Chr16, 52.67 cM
Alliance: Olig1tm1.1(cre)Rth page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:309618
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Olig1tm1.1(cre)Rth expression driven by 1 gene
 
Mutation details: The majority of the coding region for this gene was replaced with a cre-neo cassette via homologous recombination so that the cre coding sequence is joined in-frame to the endogenous gene's coding region immediately following the translation initiation site. The neo selection cassette was removed from the parental Olig1tm1(cre)Rth allele. (J:75868, J:309618)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Olig1 (mouse)
Summary of all recombinase alleles driven by Olig1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Olig1 Mutation:  14 strains or lines available
References
Original:  J:309618 Jiang M, et al., WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression. Mol Brain. 2020 Nov 13;13(1):155
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory