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Pax9tm1.1(cre)Sbam
Targeted Allele Detail
Summary
Symbol: Pax9tm1.1(cre)Sbam
Name: paired box 9; targeted mutation 1.1, Simon Bamforth
MGI ID: MGI:6760663
Synonyms: Pax9Cre
Gene: Pax9  Location: Chr12:56738552-56759607 bp, + strand  Genetic Position: Chr12, 24.53 cM
Alliance: Pax9tm1.1(cre)Sbam page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:284143
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Pax9tm1.1(cre)Sbam expression driven by 1 gene
 
Mutation details: The targeting construct was designed to replace a 1.06 kb section of the mouse Pax9 gene, spanning the second half of exon two, containing the start codon, and the first half of the 3rd exon, containing the paired box and octapeptide motif, with a promoterless Cre recombinase gene preceded by a consensus Kozak sequence and the FRT-flanked PGK-Neomycin cassette. After homologous recombination in ES cells, the FRT-flanked PGK-neomycin cassette was removed by crossing the derived mice with FLPe mice. (J:284143)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pax9 (mouse)
Summary of all recombinase alleles driven by Pax9.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pax9 Mutation:  17 strains or lines available
References
Original:  J:284143 Phillips HM, et al., Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis. Development. 2019 Sep 23;146(18):dev177618
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory