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Tppp3tm1.1(icre/ERT2)Fan
Targeted Allele Detail
Summary
Symbol: Tppp3tm1.1(icre/ERT2)Fan
Name: tubulin polymerization-promoting protein family member 3; targeted mutation 1.1, Chen-Ming Fan
MGI ID: MGI:6761418
Synonyms: Tppp3CG, Tppp3P2A-iCreERT2-T2AeGFP
Gene: Tppp3  Location: Chr8:106194125-106198158 bp, - strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Alliance: Tppp3tm1.1(icre/ERT2)Fan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:282887
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv x C57BL/6J
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tppp3tm1.1(icre/ERT2)Fan expression driven by 1 gene
 
Mutation details: The CG(2A-iCreERT2-2A-eGFP)-frt-neo-frt was inserted upstream of the stop codon of the Tppp3 gene. No coding or 3UTR (untranslated region) sequences were deleted. Germline, flp mediated recombination removed the neo cassette. (J:282887)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tppp3 (mouse)
Summary of all recombinase alleles driven by Tppp3.
 

Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tppp3 Mutation:  20 strains or lines available
References
Original:  J:282887 Harvey T, et al., A Tppp3(+)Pdgfra(+) tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis. Nat Cell Biol. 2019 Dec;21(12):1490-1503
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory