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Avpr1btm2.1(cre)Wsy
Targeted Allele Detail
Summary
Symbol: Avpr1btm2.1(cre)Wsy
Name: arginine vasopressin receptor 1B; targeted mutation 2.1, W Scott Young III
MGI ID: MGI:6764454
Synonyms: Avpr1b-Cre
Gene: Avpr1b  Location: Chr1:131526977-131539738 bp, + strand  Genetic Position: Chr1, 57.09 cM, cytoband E4
Alliance: Avpr1btm2.1(cre)Wsy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:310526
Parent Cell Line:  LC3 (ES Cell)
Strain of Origin:  (C57BL/6N x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Avpr1btm2.1(cre)Wsy expression driven by 1 gene
 
Mutation details: The Cre-nuclear localization sequence and FRT flanked pgk-neo cassette was inserted to replace the coding region from the initiating codon in exon 1 of the mouse Avpr1b gene by homologous recombination in the ES cells. The chimeras generated from correctly targetted ES cells were crossed to the FLPe deleter to remove the pgk-neo cassette. The absence of Avpr1b mRNA in brain of homozygous mice was confirmed. (J:310526)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Avpr1b (mouse)
Summary of all recombinase alleles driven by Avpr1b.
 

Expression
In Mice Carrying this Mutation: 30 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Avpr1b Mutation:  33 strains or lines available
References
Original:  J:310526 Williams Avram SK, et al., NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression. Front Behav Neurosci. 2019;13:218
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory