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Ncr1tm1(icre)Bcgen
Targeted Allele Detail
Summary
Symbol: Ncr1tm1(icre)Bcgen
Name: natural cytotoxicity triggering receptor 1; targeted mutation 1, Biocytogen LLC
MGI ID: MGI:6780080
Synonyms: Ncr1-iCre, Ncr1tm1(iCre)Bcgen, Nkp46-iCre
Gene: Ncr1  Location: Chr7:4340723-4348163 bp, + strand  Genetic Position: Chr7, 2.5 cM
Alliance: Ncr1tm1(icre)Bcgen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:311633
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Ncr1tm1(icre)Bcgen expression driven by 1 gene
 
Mutation details: An IRES-iCre sequence cassette was placed between the coding sequence of exon 7 and 3UTR of the Ncr1 gene using C57BL/6 embryonic stem cells. Neo cassette flanked by frt sites was inserted at least 300bp downstream of 3UTR. (J:308681)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ncr1 (mouse)
Summary of all recombinase alleles driven by Ncr1.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncr1 Mutation:  40 strains or lines available
References
Original:  J:311633 Bi J, et al., TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity. Sci Adv. 2021 Sep 17;7(38):eabi6515
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory