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Trpa1em1(icre)Kob
Endonuclease-mediated Allele Detail
Summary
Symbol: Trpa1em1(icre)Kob
Name: transient receptor potential cation channel, subfamily A, member 1; endonuclease-mediated mutation 1, Reiko Kobayakawa
MGI ID: MGI:6781250
Synonyms: Trpa1-Cre
Gene: Trpa1  Location: Chr1:14942872-14989086 bp, - strand  Genetic Position: Chr1, 4.5 cM
Alliance: Trpa1em1(icre)Kob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:305273
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Trpa1em1(icre)Kob expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9-mediated genome editing in the ES cells, improved-Cre was inserted at the start codon of the endogenous mouse Trpa1 locus. (J:305273)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Trpa1 (mouse)
Summary of all recombinase alleles driven by Trpa1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpa1 Mutation:  94 strains or lines available
Notes
Lentiviral gene trap injected into zygotes.
References
Original:  J:305273 Matsuo T, et al., Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation. Nat Commun. 2021 Apr 6;12(1):2074
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory