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Tbx5tm1.1(cre/ERT2)Bbr
Targeted Allele Detail
Summary
Symbol: Tbx5tm1.1(cre/ERT2)Bbr
Name: T-box 5; targeted mutation 1.1, Benoit G Bruneau
MGI ID: MGI:6790619
Synonyms: Tbx5CreERT2
Gene: Tbx5  Location: Chr5:119970733-120023284 bp, + strand  Genetic Position: Chr5, 60.42 cM
Alliance: Tbx5tm1.1(cre/ERT2)Bbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232545
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Epitope tag, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tbx5tm1.1(cre/ERT2)Bbr expression driven by 1 gene
 
Mutation details: A cDNA for Cre/ERT2, followed by an IRES element, a Kozak consensus sequence, and a 2X FLAG epitope sequence was inserted in-frame into exon 2 of the gene, upstream of the endogenous translation start site. At 40bp downstream of exon 2, cloning sites (NotI and AflII) were added and a PGK-EM7-Neo-polyA cassette, flanked by Frt sites. The neo cassette was removed by crossing with Flpe expressing mice. (J:232545)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx5 (mouse)
Summary of all recombinase alleles driven by Tbx5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx5 Mutation:  29 strains or lines available
References
Original:  J:232545 Devine WP, et al., Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife. 2014;3
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory