About   Help   FAQ
Nkx2-5tm1.1(cre/ERT2)Rard
Targeted Allele Detail
Summary
Symbol: Nkx2-5tm1.1(cre/ERT2)Rard
Name: NK2 homeobox 5; targeted mutation 1.1, Reza Ardehali
MGI ID: MGI:6791388
Synonyms: Nkx2-5/CreER
Gene: Nkx2-5  Location: Chr17:27057638-27063962 bp, - strand  Genetic Position: Chr17, 13.6 cM
Alliance: Nkx2-5tm1.1(cre/ERT2)Rard page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243421
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Nkx2-5tm1.1(cre/ERT2)Rard expression driven by 1 gene
 
Mutation details: Using homologous recombination in ES cells an internal ribosome entry site (IRES) linked to the gene encoding a nuclear-localizing recombinase cre fused to ERT2 and a hygromycin resistance gene cassette (pgk-HYGROpA) flanked by yeast flp recombinase target (frt) sites was inserted into the 3' UTR of the endogenous locus. pgk-HYGRO-pA cassette was removed by crossing to Flp recombinase gene expressing mice. (J:243421)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx2-5 (mouse)
Summary of all recombinase alleles driven by Nkx2-5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  21 strains or lines available
References
Original:  J:243421 Ranjbarvaziri S, et al., Generation of Nkx2-5/CreER transgenic mice for inducible Cre expression in developing hearts. Genesis. 2017 Aug;55(8)
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory