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Lgr5tm3(cre/ERT2)Cle
Targeted Allele Detail
Summary
Symbol: Lgr5tm3(cre/ERT2)Cle
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 3, Hans Clevers
MGI ID: MGI:6798079
Synonyms: Lgr5-ires-CreERT2, Lgr5-IRES-CreERT2
Gene: Lgr5  Location: Chr10:115286219-115423685 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance: Lgr5tm3(cre/ERT2)Cle page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lgr5tm3(cre/ERT2)Cle expression driven by 1 gene
 
Mutation details: An IRES-creERT2 cassette followed by a polyA signal and a loxP-flanked neomycin cassette was inserted into the 3' UTR of the gene. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment. (J:194551)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lgr5 (mouse)
Summary of all recombinase alleles driven by Lgr5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr5 Mutation:  58 strains or lines available
References
Original:  J:194551 Huch M, et al., In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013 Feb 14;494(7436):247-50
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory