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Agtr2em1(cre)Adk
Endonuclease-mediated Allele Detail
Summary
Symbol: Agtr2em1(cre)Adk
Name: angiotensin II receptor, type 2; endonuclease-mediated mutation 1, Annette D de Kloet
MGI ID: MGI:6834781
Synonyms: Agtr2Cre, AT2R-Cre
Gene: Agtr2  Location: ChrX:21350863-21355072 bp, + strand  Genetic Position: ChrX, 16.71 cM
Alliance: Agtr2em1(cre)Adk page
Mutation
origin
Strain of Origin:  C57BL/6J x SJL
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Agtr2em1(cre)Adk expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a viral 2A oligopeptide sequence (T2A; mediates ribosomal skipping), an SV40 nuclear localization signal, and a Cre recombinase gene were inserted into the Agtr2 gene 3'UTR. (J:316137)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Agtr2 (mouse)
Summary of all recombinase alleles driven by Agtr2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agtr2 Mutation:  11 strains or lines available
References
Original:  J:316137 Mohammed M, et al., Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice. Cardiovasc Res. 2021 Mar 16;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory