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Gfralem2(cre/ERT2)Rsy
Endonuclease-mediated Allele Detail
Summary
Symbol: Gfralem2(cre/ERT2)Rsy
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 2, Randy J Seeley
MGI ID: MGI:6834783
Synonyms: GfralCreERT
Gene: Gfral  Location: Chr9:76071389-76120939 bp, - strand  Genetic Position: Chr9, 42.48 cM
Alliance: Gfralem2(cre/ERT2)Rsy page
Mutation
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gfralem2(cre/ERT2)Rsy expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, an IRES enhancer sequence and CreER(T2) fusion gene were inserted immediately downstream of the GDNF family receptor alpha-like locus (Gfral) on chromosome 9. An ampicillin gene is segregating with the mutation of interest. (J:316128)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gfral (mouse)
Summary of all recombinase alleles driven by Gfral.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gfral Mutation:  36 strains or lines available
References
Original:  J:316128 Sabatini PV, et al., GFRAL-expressing neurons suppress food intake via aversive pathways. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2021357118
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory