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Cckbrtm1.1(cre)Mgmj
Targeted Allele Detail
Summary
Symbol: Cckbrtm1.1(cre)Mgmj
Name: cholecystokinin B receptor; targeted mutation 1.1, Martin G Myers, Jr
MGI ID: MGI:6834787
Synonyms: CckbrCre
Gene: Cckbr  Location: Chr7:105075201-105085546 bp, + strand  Genetic Position: Chr7, 55.86 cM
Alliance: Cckbrtm1.1(cre)Mgmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:316161
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Cckbrtm1.1(cre)Mgmj expression driven by 1 gene
 
Mutation details: Using homologous recombination in ES cells, a T2A sequence and a CreER(T2) fusion gene were inserted immediately downstream of the cholecystokinin B receptor locus (Cckbr) on chromosome 7. The targeting vector contained, from 5' to 3', a viral 2A oligopeptide sequence (T2A; mediates ribosomal skipping), a Cre recombinase gene, a bovine growth hormone polyA sequence, an frt site, a PGK-neo-polyA cassette, and an frt site. Founder mice were bred with Flpo-expressing mice to delete the PGK-neo-polyA cassette. (J:316161)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cckbr (mouse)
Summary of all recombinase alleles driven by Cckbr.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cckbr Mutation:  24 strains or lines available
References
Original:  J:316161 Flak JN, et al., Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020 Jun 1;130(6):2943-2952
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory