About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:158688 Seshadri S, et al., Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5622-7
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6860643
Gene symbol: Disc1
Gene name: disrupted in schizophrenia 1
Antibody: anti-mExon3
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 3B NRG1-/- left: embryonic day 10.0; Nrg1tm1Cbm/Nrg1tm1Cbm (more )
Note: Double labeled: red - Disc1; green - Tubb3 (assay MGI:6861778).
Structure Level Pattern Image Note
TS16: telencephalon Weak 3B NRG1-/- Merge left , 3B NRG1-/- DISC1 left
Specimen 3B WT left: embryonic day 10.0 (more )
Note: Double labeled: red - Disc1; green - Tubb3 (assay MGI:6861778).
Structure Level Pattern Image Note
TS16: telencephalon Present 3B WT left , 3B WT Merge left
Specimen 3B NRG1-/- right: embryonic day 10.0; Nrg1tm1Cbm/Nrg1tm1Cbm (more )
Note: Double labeled: red - Disc1; green - Nes (assay MGI:6861784).
Structure Level Pattern Image Note
TS16: telencephalon Weak 3B NRG1-/- Merge right , 3B NRG1-/- DISC1 right
Specimen 3B WT right: embryonic day 10.0; Nrg1tm1Cbm/Nrg1tm1Cbm (more )
Note: Double labeled: red - Disc1; green - Nes (assay MGI:6861784).
Structure Level Pattern Image Note
TS16: telencephalon Present 3B WT right , 3B WT Merge right
Specimen S4D BACE1-/-: postnatal day 0; Bace1tm1Pcw/Bace1tm1Pcw (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Weak S4D BASE1-/- bottom , S4D BASE1-/- top , S4D BASE1-/- Merge bottom , S4D BASE1-/- Merge top Expression in cell bodies and nuclei is similar to wild-type but there is a reduction in expression in neurites in this mutant compared to wild-type.
Specimen S4D WT: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present S4D WT top , S4D WT Merge top , S4D WT bottom , S4D WT Merge bottom
Specimen S5: postnatal adult (more )
Note: Double labeled: red - Disc1; green - Gfap (assay MGI:6861797).
Structure Level Pattern Image Note
TS28: brain Present Regionally restricted S5_DISC1 , S5_Merge Expression is in astrocytes.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory