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Lgals3em1(cre)Cya
Endonuclease-mediated Allele Detail
Summary
Symbol: Lgals3em1(cre)Cya
Name: lectin, galactose binding, soluble 3; endonuclease-mediated mutation 1, Cyagen Biosciences
MGI ID: MGI:6861775
Synonyms: Lgals3-Cre, Lgals3em1(cre)Cgen
Gene: Lgals3  Location: Chr14:47611317-47623624 bp, + strand  Genetic Position: Chr14, 24.6 cM, cytoband C1
Alliance: Lgals3em1(cre)Cya page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Recombinase)
Mutation:    Insertion
 
Lgals3em1(cre)Cya expression driven by 1 gene
 
Mutation details: A rox-flanked STOP, herpesvirus internal ribosomal entry site followed by a Cre recombinase was integrated into the endogenous Lgals3 locus after the stop codon in exon 6. A rox-flanked-STOP inserted before the IRES can be removed by dre recombinase allowing the expression cre recombinase from endogenous Lgals3 promoter. (J:318676)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lgals3 (mouse)
Summary of all recombinase alleles driven by Lgals3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgals3 Mutation:  29 strains or lines available
References
Original:  J:318676 Alencar GF, et al., Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis. Circulation. 2020 Nov 24;142(21):2045-2059
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory