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Hlfem1(cre/ERT2)Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Hlfem1(cre/ERT2)Smoc
Name: hepatic leukemia factor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI ID: MGI:7262729
Synonyms: HlfCreER
Gene: Hlf  Location: Chr11:90227362-90281721 bp, - strand  Genetic Position: Chr11, 55.03 cM
Alliance: Hlfem1(cre/ERT2)Smoc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Hlfem1(cre/ERT2)Smoc expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 genome editing technology was used to insert a 2A-Cre and rox flanked ERT2 expression cassette into the exon 4 and 3' UTR of the Hlf gene. (J:312489)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hlf (mouse)
Summary of all recombinase alleles driven by Hlf.
 

Expression
In Mice Carrying this Mutation: 18 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hlf Mutation:  17 strains or lines available
References
Original:  J:312489 Tang W, et al., Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate. Front Cell Dev Biol. 2021;9:728057
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory