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Scgb1a1tm1.1(Cicre)Thbr
Targeted Allele Detail
Summary
Symbol: Scgb1a1tm1.1(Cicre)Thbr
Name: secretoglobin, family 1A, member 1; targeted mutation 1.1, Thomas Braun
MGI ID: MGI:7263084
Synonyms: CCSP-2A-mCherry-2A-iCre-C
Gene: Scgb1a1  Location: Chr19:9061006-9065320 bp, - strand  Genetic Position: Chr19, 6.05 cM, cytoband A
Alliance: Scgb1a1tm1.1(Cicre)Thbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:323339
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Epitope tag, Recombinase, Reporter)
Mutation:    Insertion
 
Scgb1a1tm1.1(Cicre)Thbr expression driven by 1 gene
 
Mutation details: Mice were generated by inserting a 2A sequence, mCherry, 2A sequence, and the C terminal 36 amino acids of the DnaE split intein sequence from Nostoc punctiforme (Npu) fused to the C-terminal fragment of improved cre (iCre) recombinase (aa 105-343), FLAG tag, and Frt-flanked neomycin resistance cassette immediately in front of the stop codon of Scgb1a1 coding sequence by homologous recombination. The Frt-flanked neomycin resistance cassette was removed by crossing with hACTB-Flpe deleter mice. (J:323339)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Scgb1a1 (mouse)
Summary of all recombinase alleles driven by Scgb1a1.
 

Expression
In Mice Carrying this Mutation: 2 assay results
1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scgb1a1 Mutation:  29 strains or lines available
References
Original:  J:323339 Salwig I, et al., Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo. EMBO J. 2019 Jun 17;38(12):e102099
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory