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Lrp2tm1.1(cre/ERT2)Bara
Targeted Allele Detail
Summary
Symbol: Lrp2tm1.1(cre/ERT2)Bara
Name: low density lipoprotein receptor-related protein 2; targeted mutation 1.1, Jonathan Barasch
MGI ID: MGI:7279146
Synonyms: Lrp2CreERT2, Megalin3'Cre-Ert
Gene: Lrp2  Location: Chr2:69254679-69416373 bp, - strand  Genetic Position: Chr2, 40.74 cM
Alliance: Lrp2tm1.1(cre/ERT2)Bara page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:324326
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lrp2tm1.1(cre/ERT2)Bara expression driven by 1 gene
 
Mutation details: The translational STOP (TAG) codon of the Lrp2 gene was replaced with P2a-CreERT2-frt-neo-frt cassette. The Neo cassette was removed by crossing Actin-Flpe mice. (J:324326)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lrp2 (mouse)
Summary of all recombinase alleles driven by Lrp2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp2 Mutation:  261 strains or lines available
References
Original:  J:324326 Shen TH, et al., Snapshots of nascent RNA reveal cell- and stimulus-specific responses to acute kidney injury. JCI Insight. 2022 Mar 22;7(6):e146374
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory