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Hoxb8em1(flpo)Vabr
Endonuclease-mediated Allele Detail
Summary
Symbol: Hoxb8em1(flpo)Vabr
Name: homeobox B8; endonuclease-mediated mutation 1, Victoria Abraira
MGI ID: MGI:7282054
Gene: Hoxb8  Location: Chr11:96172731-96176141 bp, + strand  Genetic Position: Chr11, 59.82 cM
Alliance: Hoxb8em1(flpo)Vabr page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Hoxb8em1(flpo)Vabr expression driven by 1 gene
 
Mutation details: CRISPR/cas9 endonuclease-mediated genome editing was used to insert a codon optimized T2A-Flpo sequence just before the stop codon in the 3' UTR. Endogenous Hox8b gene function is not disrupted. (J:339474)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hoxb8 (mouse)
Summary of all recombinase alleles driven by Hoxb8.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:  8 strains or lines available
References
Original:  J:339474 Bohic M, et al., A new Hoxb8FlpO mouse line for intersectional approaches to dissect developmentally defined adult sensorimotor circuits. Front Mol Neurosci. 2023;16:1176823
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory