About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:243375 Choi D, et al., Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03;127(4):1225-1240
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7310037
Gene symbol: Lyve1
Gene name: lymphatic vessel endothelial hyaluronan receptor 1
Results
Specimen 3A WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: back skin Present 3A WT Lymphatic enlarged , 3A WT Lymphatic
TS23: lymphatic vessel Present 3A WT Lymphatic enlarged , 3A WT Lymphatic

Specimen 3A Orai1KO: embryonic day 15.5; Orai1tm1Rao/Orai1tm1Rao (more )
Structure Level Pattern Image Note
TS23: back skin Present 3A KO Lymphatic , 3A KO Lymphatic enlarged This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.
TS23: lymphatic vessel Present 3A KO Lymphatic , 3A KO Lymphatic enlarged This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.

Specimen 3B WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: ear Present Regionally restricted 3B WT Lymphatic enlarged , 3B WT Lymphatic
TS23: lymphatic vessel Present Regionally restricted 3B WT Lymphatic enlarged , 3B WT Lymphatic

Specimen 3B Orai1KO: embryonic day 15.5; Orai1tm1Rao/Orai1tm1Rao (more )
Structure Level Pattern Image Note
TS23: ear Present 3B KO Lymphatic , 3B KO Lymphatic enlarged This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.
TS23: lymphatic vessel Present 3B KO Lymphatic , 3B KO Lymphatic enlarged This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.

Specimen 6I WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: back skin Present 6I WT LYVE-1 left , 6I WT LYVE-1 right
TS23: lymphatic vessel Present 6I WT LYVE-1 left , 6I WT LYVE-1 right

Specimen 6I KO: embryonic day 15.5; Dtx3lem1Ykho/Dtx3lem1Ykho (more )
Structure Level Pattern Image Note
TS23: back skin Present 6I KO LYVE-1 left , 6I KO LYVE-1 right Mutant embryos displayed defective lymphatic sprouting with a reduced number of branching points and an increased distance between the branching points compared to wild-type. Mutant ymphatic vessels had atypical dull and round vessel tips.
TS23: lymphatic vessel Present 6I KO LYVE-1 left , 6I KO LYVE-1 right Mutant embryos displayed defective lymphatic sprouting with a reduced number of branching points and an increased distance between the branching points compared to wild-type. Mutant ymphatic vessels had atypical dull and round vessel tips.

Specimen S3 C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: back skin Present S3C
TS23: lymphatic vessel Present S3C

Specimen S3 D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: back skin Present S3D
TS23: lymphatic vessel Present S3D

Specimen S3 G: embryonic day 15.5; Orai1tm1Rao/Orai1tm1Rao (more )
Structure Level Pattern Image Note
TS23: back skin Present S3G This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.
TS23: lymphatic vessel Present S3G This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.

Specimen S3 H: embryonic day 15.5; Orai1tm1Rao/Orai1tm1Rao (more )
Structure Level Pattern Image Note
TS23: back skin Present S3H This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.
TS23: lymphatic vessel Present S3H This mutant has abnormally enlarged lymphatic vessels with reduced number of sprouts and branches compared to wild-type.

Specimen S11 A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: back skin Present S11A
TS23: lymphatic vessel Present S11A

Specimen S11 B: embryonic day 15.5; Dtx3lem1Ykho/Dtx3lem1Ykho (more )
Structure Level Pattern Image Note
TS23: back skin Present S11B Mutant embryos displayed defective lymphatic sprouting with a reduced number of branching points and an increased distance between the branching points compared to wild-type. Mutant ymphatic vessels had atypical dull and round vessel tips.
TS23: lymphatic vessel Present S11B Mutant embryos displayed defective lymphatic sprouting with a reduced number of branching points and an increased distance between the branching points compared to wild-type. Mutant ymphatic vessels had atypical dull and round vessel tips.

Specimen S11 C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: back skin Present S11C
TS23: lymphatic vessel Present S11C

Specimen S11 D: embryonic day 15.5; Dtx3lem1Ykho/Dtx3lem1Ykho (more )
Structure Level Pattern Image Note
TS23: back skin Present S11D Mutant embryos displayed defective lymphatic sprouting with a reduced number of branching points and an increased distance between the branching points compared to wild-type. Mutant ymphatic vessels had atypical dull and round vessel tips.
TS23: lymphatic vessel Present S11D Mutant embryos displayed defective lymphatic sprouting with a reduced number of branching points and an increased distance between the branching points compared to wild-type. Mutant ymphatic vessels had atypical dull and round vessel tips.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
09/17/2024
MGI 6.24
The Jackson Laboratory