Tg(Slc6a3-tTA)2Kftnk
Transgene Detail
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Symbol: |
Tg(Slc6a3-tTA)2Kftnk |
Name: |
transgene insertion 2, Kenji Tanaka |
MGI ID: |
MGI:7316790 |
Synonyms: |
Slc6a3-tTA BAC |
Transgene: |
Tg(Slc6a3-tTA)2Kftnk Location: unknown Genetic Position: ChrUN, Syntenic
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Alliance: |
Tg(Slc6a3-tTA)2Kftnk page
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Transgene Type: |
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Transgenic (Transactivator) |
Mutation: |
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Insertion
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Tg(Slc6a3-tTA)2Kftnk expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Slc6a3 (MGI:94862) |
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Mutation details: BAC clone RP24-158J12 carrying mouse Slc6a3 (also carrying Lpcat1 (short isoform) and Clptm1l) was modified with a mammalianized tTA-Sv40 polyA signal introduced into the translation initiation site. The transgenic insertion site is unknown, but qPCR suggests that two copies of the BAC were integrated in the genome. A residual FRT and loxP site remain in the 3' end of the modified Slc6a3 segment. Founder line 2 carries higher transgene penetrance in dopamine neurons.
(J:326690)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:326690 Amo R, et al., A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning. Nat Neurosci. 2022 Jul 7; |
All: |
1 reference(s) |
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