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Gene Expression Data
Assay Details
Assay
Reference: J:284490 Varum S, et al., Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7332911
Gene symbol: Yy1
Gene name: YY1 transcription factor
Antibody: anti-YY1 (H-414; sc-1703)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: Two antibodies were described, but the one used in this assay was not detailed. YY1 antibody MGI:7332852 may have been used in this assay.
Results
Specimen S1A Control: embryonic day 9.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre.
Structure Cell Type Level Pattern Image Note
TS15: branchial arch premigratory neural crest cell Present S1A Control
Specimen S1A Yy1 cko: embryonic day 9.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS15: branchial arch premigratory neural crest cell Absent S1A Yy1 cko Expression specifically depleted in pre-migratory neural crest cells.
Specimen S1B Control: embryonic day 9.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: green - Yy1; red - Sox10 (assay MGI:7332913).
Structure Cell Type Level Pattern Image Note
TS15: migrating neural crest migratory trunk neural crest cell Present S1B Control
Specimen S1B Yy1 cko: embryonic day 9.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: green - Yy1; red - Sox10 (assay MGI:7332913).
Structure Cell Type Level Pattern Image Note
TS15: migrating neural crest migratory trunk neural crest cell Present S1B Yy1 cko
Specimen S4B Control: embryonic day 9.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre. Double labeled: green - Yy1; red - Casp3 (assay MGI:7332926).
Structure Cell Type Level Pattern Image Note
TS15: branchial arch premigratory neural crest cell Present S4B Control
Specimen S4B Yy1 cko: embryonic day 9.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant. Double labeled: green - Yy1; red - Casp3 (assay MGI:7332926).
Structure Cell Type Level Pattern Image Note
TS15: branchial arch premigratory neural crest cell Absent S4B Yy1 cko Expression specifically depleted in pre-migratory neural crest cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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