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Islrtm1.1(HBEGF,cre)Mat
Targeted Allele Detail
Summary
Symbol: Islrtm1.1(HBEGF,cre)Mat
Name: immunoglobulin superfamily containing leucine-rich repeat; targeted mutation 1.1, Masahide Takahashi
MGI ID: MGI:7335155
Synonyms: Islrtm1.1(ZsGreen/DTR/cre)Mat, Meflin-ZDC
Gene: Islr  Location: Chr9:58063547-58066563 bp, - strand  Genetic Position: Chr9, 31.63 cM
Alliance: Islrtm1.1(HBEGF,cre)Mat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:280029
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout, Recombinase, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Islrtm1.1(HBEGF,cre)Mat expresses 1 gene
 
Islrtm1.1(HBEGF,cre)Mat expression driven by 1 gene
 
Mutation details: The targeting construct replaced the open reading frame with a ZsGreen reporter gene, t2a sequence, human diphtheria toxin receptor (HBEGF), t2a sequence, and cre recombinase gene. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:280029)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Islr (mouse)
Summary of all recombinase alleles driven by Islr.
 

Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Islr Mutation:  23 strains or lines available
References
Original:  J:280029 Mizutani Y, et al., Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis. Cancer Res. 2019 Oct 15;79(20):5367-5381
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory