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Gene Expression Data
Assay Details
Assay
Reference: J:116586 Li H, et al., Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci. 2006 Oct;33(2):136-49
Assay type: RNA in situ
MGI Accession ID: MGI:7367165
Gene symbol: Tenm4
Gene name: teneurin transmembrane protein 4
Probe: Odz4 cDNA1
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 3D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cerebral cortex subventricular zone Present Graded 3D Expression is in a rostral low to caudal high gradient.
TS23: cerebral cortex ventricular layer Present Graded 3D Expression is in a rostral low to caudal high gradient.
TS23: cortical plate Present Graded 3D Expression is in a rostral low to caudal high gradient.
TS23: hippocampus Present 3D
TS23: thalamus Present 3D

Specimen 3D': embryonic day 15.5; Emx2tm1Pgr/Emx2tm1Pgr (more )
Structure Level Pattern Image Note
TS23: cerebral cortex subventricular zone Weak 3D' In this mutant the expression gradient has almost completely flattened out compared to wild-type.
TS23: cerebral cortex ventricular layer Weak 3D' In this mutant the expression gradient has almost completely flattened out compared to wild-type.
TS23: cortical plate Weak 3D' In this mutant the expression gradient has almost completely flattened out compared to wild-type.
TS23: hippocampus Present 3D' Expression in this tissue was less affected in this mutant compared to wild-type.
TS23: thalamus Present 3D' Expression in this tissue was less affected in this mutant compared to wild-type.

Specimen 4E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Graded 4E Expression is in a rostral low to caudal high gradient.
TS26: corpus striatum Present 4E
TS26: dentate gyrus Present 4E
TS26: hippocampus Present 4E
TS26: main olfactory bulb Present 4E
TS26: thalamus Present 4E
TS26: cortical plate Present Graded 4E Expression increased from anterior to posterior.
TS26: cerebral cortex subventricular zone Present Uniform 4E
TS26: cerebral cortex ventricular zone Present Uniform 4E
TS26: neocortex Present Regionally restricted 4E Expression is uniform in layer V.

Specimen 4E': embryonic day 18.5; Emx2tm1Pgr/Emx2tm1Pgr (more )
Structure Level Pattern Image Note
TS26: cortical plate Weak Regionally restricted 4E' In this mutant the expressing region was reduced and had shifted towards the most posterior end compared to wild-type.
TS26: cerebral cortex subventricular zone Present 4E' The band of expressing cells was broader compared to wild-type.
TS26: cerebral cortex ventricular zone Present 4E' The band of expressing cells was broader compared to wild-type.
TS26: neocortex Present Regionally restricted 4E' Expression in layer V was similar to wild-type.

Specimen 4F: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: corpus striatum Present 4F
TS26: dentate gyrus Present 4F
TS26: hippocampus Present 4F
TS26: main olfactory bulb Present 4F
TS26: thalamus Present 4F
TS26: cerebral cortex Present Graded 4F Expression is in a rostral low to caudal high gradient.
TS26: cortical plate Present Graded 4F Expression increased from anterior to posterior.
TS26: cerebral cortex subventricular zone Present Uniform 4F
TS26: cerebral cortex ventricular zone Present Uniform 4F
TS26: neocortex Present Regionally restricted 4F Expression is uniform in layer V.

Specimen 4F': embryonic day 18.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Strong 4F'
TS26: cortical plate Strong Regionally restricted 4F' In this mutant the expressing area has expanded/shifted towards the anterior.
TS26: cerebral cortex subventricular zone Present 4F' The band of expressing cells was broader compared to wild-type.
TS26: cerebral cortex ventricular zone Present 4F' The band of expressing cells was broader compared to wild-type.

Specimen 5D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cortical plate Present Graded 5D Expression is differentiating cells in a rostral low to caudal high gradient.
TS23: cerebral cortex subventricular zone Present Graded 5D Expression is proliferating cells in a rostral low to caudal high gradient.
TS23: cerebral cortex ventricular layer Present Graded 5D Expression is proliferating cells in a rostral low to caudal high gradient.
TS23: corpus striatum Present 5D
TS23: hippocampus Present 5D
TS23: main olfactory bulb Present 5D
TS23: thalamus Present 5D

Specimen 5H: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral cortex subventricular zone Present Graded 5H Expression is in a rostral low to caudal high gradient.
TS26: cerebral cortex ventricular zone Present Graded 5H Expression is in a rostral low to caudal high gradient.
TS26: cortical plate Present Graded 5H Expression is in a rostral low to caudal high gradient.
TS26: neocortex region Present Regionally restricted 5H Expression is in the orbital area.
TS26: insular cortex Present 5H

Specimen 6D: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex subventricular zone Present Graded 6D Expression is in a rostral low to caudal high gradient.
TS27: cerebral cortex ventricular zone Present Graded 6D Expression is in a rostral low to caudal high gradient.
TS27: cortical plate Present Graded 6D Expression is in a rostral low to caudal high gradient.
TS27: cortical layer V Present Graded 6D Expression is in a decreasing gradient from the posterior part to the most anterior part of cortex.
TS27: visual cortex Strong 6D
TS27: corpus striatum Present 6D
TS27: insular cortex Present 6D
TS27: thalamus Present 6D
TS27: neocortex region Present Regionally restricted 6D Expression is in the orbital area.
TS27: hippocampus Present Regionally restricted 6D

Specimen 7D: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cortical layer V Very strong Graded 7D Expression is rostral low and caudal high.
TS28: cortical layer II Strong Graded 7D Expression is rostral low and caudal high. Expression terminates abruptly at the border between somatosensory and visual area.
TS28: cortical layer III Strong Graded 7D Expression is rostral low and caudal high. Expression terminates abruptly at the border between somatosensory and visual area.
TS28: cortical layer IV Strong Graded 7D Expression is rostral low and caudal high. Expression terminates abruptly at the border between somatosensory and visual area.
TS28: cortical layer VI Strong Graded 7D Expression is rostral low and caudal high. Expression terminates abruptly at the border between somatosensory and visual area.
TS28: cortical layer I Present Graded 7D Expression is rostral low and caudal high.
TS28: hippocampus CA1 Strong 7D
TS28: dentate gyrus Present 7D

Specimen 8D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present Graded 8D Expression is in a high dorsal/medial to low ventral/lateral gradient.
TS23: dorsal thalamus Present Regionally restricted 8D Expression is in in the posterior complex and centrolateral nucleus and is absent in the ventroposterior nucleus.
TS23: dorsal lateral geniculate nucleus Present 8D
TS23: geniculate thalamic group Present Regionally restricted 8D Expression is in the ventral subdivision of medial geniculate nucleus.

Specimen 8H: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present Graded 8H Expression is in in a high medial and low lateral gradient.
TS27: dorsal lateral geniculate nucleus Strong 8H
TS27: lateral posterior thalamic nucleus Strong 8H
TS27: visual cortex Strong 8H
TS27: central lateral thalamic nucleus Present 8H
TS27: posterior thalamic group Present 8H

Specimen not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forebrain Weak


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory