Tg(Prnp-CHCHD10*R15L)U2Dkan
Transgene Detail
|
|
| Symbol: |
Tg(Prnp-CHCHD10*R15L)U2Dkan |
| Name: |
transgene insertion U2, David Kang |
| MGI ID: |
MGI:7380620 |
| Synonyms: |
CHCHD10-R15L |
| Transgene: |
Tg(Prnp-CHCHD10*R15L)U2Dkan Location: unknown Genetic Position: ChrUN, Syntenic
|
| Alliance: |
Tg(Prnp-CHCHD10*R15L)U2Dkan page
|
|
|
|
| Transgene Type: |
|
Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Tg(Prnp-CHCHD10*R15L)U2Dkan expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CHCHD10 (400916) |
|
contains R15L mutation |
|
| |
|
Mutation details: The transgenic construct contains FLAG-tagged human CHCHD10 R15L mutant cDNA cloned into the expression vector MoPrP.Xho, which contains the mouse genomic prion promoter (Prnp) sequence.
(J:306293)
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
| Original: |
J:306293 Liu T, et al., CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia. FASEB J. 2020 Jun;34(6):8493-8509 |
| All: |
3 reference(s) |
|
Analysis Tools
