Slc18a1<em3(icre)Mkwt> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7413203)

Slc18a1^{em3(icre)Mkwt}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Slc18a1^{em3(icre)Mkwt}
Name:	solute carrier family 18 (vesicular monoamine), member 1; endonuclease-mediated mutation 3, Masakado Kawata
MGI ID:	MGI:7413203
Synonyms:	Vmat1^iCre
Gene:	Slc18a1 Location: Chr8:69490363-69541887 bp, - strand Genetic Position: Chr8, 33.88 cM
Alliance:	Slc18a1^{em3(icre)Mkwt} page

Mutation
origin

Strain of Origin:

Mutation
description

Allele Type:

Endonuclease-mediated (Recombinase)

Mutation:

Insertion

Slc18a1^{em3(icre)Mkwt} expression driven by 1 gene

Mutation details: CRISPR-targeting exon 17 inserted a T2A sequence and improved cre recombinase gene (icre) at the STOP codon. (J:330805)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc18a1 (mouse) Summary of all recombinase alleles driven by Slc18a1. Alliance mouse Slc18a1 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Slc18a1 Mutation:	22 strains or lines available

References

Original:	J:330805 Sato DX, et al., Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety. iScience. 2022 Aug 19;25(8):104800
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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