Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav
Transgene Detail
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| Symbol: |
Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav |
| Name: |
transgene insertion 13, Dario AA Vignali |
| MGI ID: |
MGI:7414283 |
| Synonyms: |
ThPOKF/F.iCreERT2.hCD2 |
| Transgene: |
Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav Location: unknown Genetic Position: Chr13, Syntenic
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| Alliance: |
Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav page
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| Transgene Type: |
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Transgenic (Conditional ready, Epitope tag, Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Zbtb7b (MGI:102755) |
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Mutation details: A 562base pair fragment of the Zbtb7b silencer sequence was inserted into a mini-transgene containing the minimal Cd4 enhancer-promoter-FRT-icre/ERT2. A FRT site was inserted 1086bp upstream of the ATG codon of the icre/ERT2. The sequence encoding an internal ribosomal entry site and human CD2 were also inserted downstream of the cDNA cassette encoding icre/ERT2 and additional FRT site was inseted after the STOP codon of the CD2. The transgene expresses Cre specifically in the CD4 lineage. Founder information was not available. Line number 13 was assigned for the transgene inserted into chromosome 13 at approximately 13D1.
(J:312516)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Zbtb7b
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:312516 Andrews LP, et al., A Cre-driven allele-conditioning line to interrogate CD4(+) conventional T cells. Immunity. 2021 Oct 12;54(10):2209-2217.e6 |
| All: |
1 reference(s) |
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Analysis Tools
