Tg(Dct-cre/ERT2)40ALru
Transgene Detail
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| Symbol: |
Tg(Dct-cre/ERT2)40ALru |
| Name: |
transgene insertion 40A, Lionel Larue |
| MGI ID: |
MGI:7425240 |
| Synonyms: |
Dct::CreERT2 |
| Transgene: |
Tg(Dct-cre/ERT2)40ALru Location: unknown
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| Alliance: |
Tg(Dct-cre/ERT2)40ALru page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Dct-cre/ERT2)40ALru expression driven by
1 gene
Transgene expression driven by:
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Mutation details: A 6.7 kb transgenic vector was generated including the mouse dopachrome tautomerase (Dct) promoter driving expression of a cre/ERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) followed by an SV40 polyadenylation sequence. The founder line 40A, with approximately 60 copies of the transgene inserted into the H4 region (AC121292.9) of chromosome 1 in an intergenic region between the H3.3 histone A (H3f3a) and the SDE2 telomere maintenance homolog (S. pombe) (Sde2) genes, was established.
(J:314330)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Dct
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:314330 Le Coz M, et al., Targeted Knockout of beta-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreER(T2), Results in Disrupted Stem Cell Renewal and Pigmentation Defects. J Invest Dermatol. 2021 May;141(5):1363-1366.e9 |
| All: |
1 reference(s) |
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Analysis Tools
